Denali Therapeutics Inc

NASDAQ:DNLI USA Biotechnology
Market Cap
$3.23 Billion
Market Cap Rank
#4145 Global
#2623 in USA
Share Price
$20.71
Change (1 day)
+0.68%
52-Week Range
$11.47 - $22.74
All Time High
$93.56
About

Denali Therapeutics Inc., a biopharmaceutical company, discovers and develops therapeutics to treat neurodegenerative and lysosomal storage diseases. The company develops Eclitasertib (SAR443122/DNL758) RIPK1 inhibitor program for peripheral inflammatory diseases; DNL343 eIF2B activator program for amyotrophic lateral sclerosis; BIIB122/DNL151 LRRK2 inhibitor program for Parkinson's disease; TAK-… Read more

Market Cap & Net Worth: Denali Therapeutics Inc (DNLI)

Denali Therapeutics Inc (NASDAQ:DNLI) has a market capitalization of $3.23 Billion ($3.23 Billion) as of March 19, 2026. Listed on the NASDAQ stock exchange, this USA-based company holds position #4145 globally and #2623 in its home market, demonstrating a -2.82% decrease in market value over the past year.

Market capitalization, also known as net worth in stock markets, is calculated by multiplying Denali Therapeutics Inc's stock price $20.71 by its total outstanding shares 156158364 (156.16 Million).

Denali Therapeutics Inc Market Cap History: 2017 to 2026

Denali Therapeutics Inc's market capitalization history from 2017 to 2026. Data shows change from $2.44 Billion to $3.23 Billion (-0.42% CAGR).

Index Memberships

Denali Therapeutics Inc is a constituent of 3 market indices:

Index Total Market Cap Weight (%) Rank by Market Cap
NASDAQ Health Care
IXHC
$2.24 Trillion 0.12% #105 of 976
NASDAQ Composite
IXIC
$33.39 Trillion 0.01% #508 of 3165
NASDAQ Biotechnology
NBI
$1.54 Trillion 0.18% #64 of 263

Weight: Denali Therapeutics Inc's market cap as a percentage of total index value. Rank: Position among all constituents by market cap.

Denali Therapeutics Inc Market Cap to Earnings & Revenue Ratios Timeline

This chart shows how Denali Therapeutics Inc's valuation ratios have evolved. The Price to Sales (P/S) ratio compares market cap to revenue, while the Price to Earnings (P/E) ratio compares market cap to net income. Lower values may indicate a more undervalued company relative to its financial performance.

Latest Price to Sales (P/S) Ratio

10.14x

Denali Therapeutics Inc's market cap is 10.14 times its annual revenue

Industry average:
1728.56x
Lower than industry average

Latest Price to Earnings (P/E) Ratio

N/A

P/E ratio not applicable due to negative or zero earnings

What These Ratios Tell Investors:
  • Price to Sales (P/S) Ratio: Shows how much investors are paying for each dollar of the company's sales. Lower P/S ratios may indicate undervaluation.
  • Price to Earnings (P/E) Ratio: Shows how much investors are paying for each dollar of the company's earnings. This is one of the most common valuation metrics.
  • Trends in these ratios over time can indicate changing investor sentiment about the company's future growth prospects.
  • Industry comparison provides context for whether the company is valued higher or lower than peers.
Year Market Cap (USD) Revenue (USD) Net Income (USD) P/S Ratio P/E Ratio
2018 $3.23 Billion $129.16 Million -$36.24 Million 24.98x N/A
2019 $2.72 Billion $26.68 Million -$197.61 Million 101.97x N/A
2020 $13.08 Billion $335.66 Million $71.14 Million 38.97x 183.87x
2021 $6.96 Billion $48.66 Million -$290.58 Million 143.13x N/A
2022 $4.34 Billion $108.46 Million -$325.99 Million 40.04x N/A
2023 $3.35 Billion $330.53 Million -$145.22 Million 10.14x N/A

Competitor Companies of DNLI by Market Capitalization

Companies near Denali Therapeutics Inc in the global market cap rankings as of March 19, 2026.

Key companies related to Denali Therapeutics Inc by market ranking:

  • Vertex Pharmaceuticals Inc (NASDAQ:VRTX): Ranked #162 globally with a market cap of $117.09 Billion USD.
  • Regeneron Pharmaceuticals Inc (NASDAQ:REGN): Ranked #281 globally with a market cap of $74.80 Billion USD.
  • CSL Limited (PINK:CMXHF): Ranked #344 globally with a market cap of $63.46 Billion USD.
  • argenx SE (OTCGREY:ARGNF): Ranked #500 globally with a market cap of $42.99 Billion USD.

Market capitalization comparison (in billions USD)
Rank Company Symbol Market Cap Price
#162 Vertex Pharmaceuticals Inc NASDAQ:VRTX $117.09 Billion $462.49
#281 Regeneron Pharmaceuticals Inc NASDAQ:REGN $74.80 Billion $759.05
#344 CSL Limited PINK:CMXHF $63.46 Billion $149.87
#500 argenx SE OTCGREY:ARGNF $42.99 Billion $697.42

Denali Therapeutics Inc Historical Marketcap From 2017 to 2026

Between 2017 and today, Denali Therapeutics Inc's market cap moved from $2.44 Billion to $ 3.23 Billion, with a yearly change of -0.42%.

Year Market Cap Change (%)
2026 $3.23 Billion +25.44%
2025 $2.58 Billion -18.99%
2024 $3.18 Billion -5.03%
2023 $3.35 Billion -22.83%
2022 $4.34 Billion -37.65%
2021 $6.96 Billion -46.75%
2020 $13.08 Billion +380.83%
2019 $2.72 Billion -15.68%
2018 $3.23 Billion +32.10%
2017 $2.44 Billion --

End of Day Market Cap According to Different Sources

On Mar 18th, 2026 the market cap of Denali Therapeutics Inc was reported to be:

Source Market Cap
Yahoo Finance $3.23 Billion USD
MoneyControl $3.23 Billion USD
MarketWatch $3.23 Billion USD
marketcap.company $3.23 Billion USD
Reuters $3.23 Billion USD

Market cap values may vary slightly between sources due to differences in calculation methods, timing, and data refresh rates.