Ionis Pharmaceuticals Inc (IONS) — Cash Flow-to-Debt Ratio
Ionis Pharmaceuticals Inc (IONS) has a Cash Flow-to-Debt Ratio of 0.22x as of June 2026, meaning its operating cash flow of $565.53 Million could theoretically repay 0% of its total liabilities ($2.56 Billion) in one year. See Ionis Pharmaceuticals Inc (IONS) financial flexibility to measure the company's free cash flow as a share of total liabilities.
CF-to-Debt Ratio
Operating Cash Flow
Total Liabilities
Data as of
Ionis Pharmaceuticals Inc Cash Flow-to-Debt Ratio (1991–2025)
Historical debt coverage capacity for Ionis Pharmaceuticals Inc across 35 annual periods. For the full cash flow conversion analysis, see Ionis Pharmaceuticals Inc (IONS) cash conversion ratio.
Annual Cash Flow-to-Debt Ratio for Ionis Pharmaceuticals Inc (1991–2025)
Year-by-year debt coverage analysis for Ionis Pharmaceuticals Inc. Check Ionis Pharmaceuticals Inc cash flow quality index to evaluate the quality of earnings relative to operating cash generation.
| Year | CF-to-Debt Ratio | Operating CF (USD) | Total Liabilities | YoY Change |
|---|---|---|---|---|
| 2025 | -0.09x | $-268.58 Million | $3.03 Billion | ▲ +57.3% |
| 2024 | -0.21x | $-500.95 Million | $2.42 Billion | ▼ -75.6% |
| 2023 | -0.12x | $-307.51 Million | $2.60 Billion | ▲ +15.6% |
| 2022 | -0.14x | $-274.37 Million | $1.96 Billion | ▼ -935.9% |
| 2021 | 0.02x | $30.80 Million | $1.84 Billion | ▼ -27.9% |
| 2020 | 0.02x | $35.89 Million | $1.55 Billion | ▼ -89.6% |
| 2019 | 0.22x | $345.72 Million | $1.55 Billion | ▼ -45.2% |
| 2018 | 0.41x | $602.89 Million | $1.48 Billion | ▲ +111.2% |
| 2017 | 0.19x | $174.15 Million | $903.30 Million | ▲ +239.8% |
| 2016 | -0.14x | $-112.11 Million | $812.90 Million | ▼ -593.1% |
| 2015 | 0.03x | $21.12 Million | $755.32 Million | ▲ +210.6% |
| 2014 | 0.01x | $6.29 Million | $698.03 Million | ▼ -93.4% |
| 2013 | 0.14x | $63.49 Million | $468.77 Million | ▲ +2520.3% |
| 2012 | 0.01x | $1.88 Million | $362.92 Million | ▲ +101.4% |
| 2011 | -0.37x | $-114.80 Million | $313.46 Million | ▼ -76.2% |
| 2010 | -0.21x | $-63.59 Million | $305.94 Million | ▲ +31.9% |
| 2009 | -0.31x | $-108.44 Million | $355.12 Million | ▼ -167.7% |
| 2008 | 0.45x | $212.03 Million | $469.90 Million | ▲ +210.8% |
| 2007 | 0.15x | $36.09 Million | $248.62 Million | ▲ +143.1% |
| 2006 | -0.34x | $-53.23 Million | $158.00 Million | ▲ +10.7% |
| 2005 | -0.38x | $-61.74 Million | $163.71 Million | ▼ -4.0% |
| 2004 | -0.36x | $-101.75 Million | $280.56 Million | ▼ -1.7% |
| 2003 | -0.36x | $-95.47 Million | $267.76 Million | ▼ -7.0% |
| 2002 | -0.33x | $-94.38 Million | $283.21 Million | ▼ -949.7% |
| 2001 | -0.03x | $-6.16 Million | $193.96 Million | ▲ +84.0% |
| 2000 | -0.20x | $-23.19 Million | $116.89 Million | ▲ +58.1% |
| 1999 | -0.47x | $-48.40 Million | $102.31 Million | ▼ -36.7% |
| 1998 | -0.35x | $-34.70 Million | $100.30 Million | ▼ -39.4% |
| 1997 | -0.25x | $-20.60 Million | $83.00 Million | ▲ +49.8% |
| 1996 | -0.49x | $-21.20 Million | $42.90 Million | ▲ +22.4% |
| 1995 | -0.64x | $-15.10 Million | $23.70 Million | ▲ +13.7% |
| 1994 | -0.74x | $-15.20 Million | $20.60 Million | ▲ +2.1% |
| 1993 | -0.75x | $-15.30 Million | $20.30 Million | ▲ +39.0% |
| 1992 | -1.24x | $-19.40 Million | $15.70 Million | ▼ -1094.5% |
| 1991 | -0.10x | $-1.50 Million | $14.50 Million | — |